NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2021, Vol. 33 ›› Issue (7): 1165-1171.doi: 10.16333/j.1001-6880.2021.7.011

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Study on the secondary metabolites from the deep-sea-derived fungus Neoroussoella sp.and their biological activities 

ZHONG Jin-qian1,2,CHEN Yu-chan2,CHEN Shan-chong2,LIU Zhao-ming2,LIU Hong-xin2,ZHANG Wei-min2*,YAN Han-jing1*   

  1. 1School of Traditional Chinese Medicine,Guangdong Pharmaceutical University,Guangzhou 510006,China;2 Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application,State Key Laboratory of Applied Microbiology Southern China,Institute of Microbiology,Guangdong Academy of Sciences, Guangzhou 510070,China

  • Online:2021-07-28 Published:2021-07-29


The secondary metabolites of a deep-sea-derived fungus Neoroussoella sp. FS526 and their biological activities were investigated.The solid fermentation extraction of strain FS526 was isolated and purified by silica gel column,Sephadex LH-20 gel column,and high performance liquid chromatography,which led to the isolation of fifteen known compounds.The chemical structures of the isolates were identified by spectrum analysis as amestolkolide B (1),thailandolide B (2),aspergillumarins A-B (3 and 4),de-O-methyldiaporthin (5),4-(2-acetoxyethyl)phenol (6),5,6,8-trihydroxy-4-(1′-hydroxyethyl)isocoumarin (7),sescandelin (8),penicifuran A (9),7-hydroxy-5-methoxy-4,6-dimethylphthalidc (10),pestalotiolactone A (11),2′,4′-dihydroxy-6′-methoxy-3′-methylacetophenone (12),1-(2,4-dihydroxy-6-methoxy-3-methylphenyl)ethanone (13),2,5-dimethylresorcinol (14),and 3,5-dihydroxytoluene (15).All the isolated compounds were firstly reported from the genus Neoroussoella.Compound 1 showed weak cytotoxic activity with the IC50 values of 41.44-77.89 μM,and compound 7 showed strong antioxidant activity with the IC50 value of 13.93 μM.

Key words: deep-sea-derived fungus, Neoroussoella , sp., secondary metabolites, cytotoxic activity, antioxidant activity

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