NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2022, Vol. 34 ›› Issue (1): 70-75.doi: 10.16333/j.1001-6880.2022.1.010

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Study on chemical composition and antioxidant activity of solid fermented product of soil fungus Aspergillus fumigatus

ZHAO Jiang-yuan1＃,FAN Xiao-yi2＃,ZOU Xue-feng3,YANG Pei-wen4,TANG Shu-kun1,LI Ming-gang1*,LIU Shi-wei2,DING Jian-hai2*   

  1. 1School of Life Sciences,Yunnan University,Kunming 650091,China;2College of Chemistry and Chemical Engineering,Ningxia Normal University,Guyuan 756000,China;3College of Plant Protection,Yunnan Agricultural University,Kunming 650201, China;  4Institute of Agricultural Environment and Resources,Yunnan Academy of Agricultural Sciences,Kunming 650205,China
  • Online:2022-01-28 Published:2022-01-28

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Abstract:

To study the chemical constituents of the fungus Aspergillus fumigatus isolated from a soil sample collected from the Ailao Mountain area.Thirteen compounds,rubrofusarin B (1),rubrofusarin A (2),carbonarone A (3),aspernigrin A (4),flavasperone (5),(22E,24R)-5α,8α-epidioxy-ergosta-6,22-dien-3β-ol (6),(22E,24R)-5α,8α-epidioxy-ergosta-6,9 (11),22-dien-3β-ol (7),ourosperone A (8),ergosta-5,7,22-trien-3β-ol (9),stigmast-1,5-dien-3β-ol (10),fonsecinones A (11),asperpyrone C (12),asperpyrones B (13) were isolated from the fungus with the help of the silica gel,Rp-18 and Sephadex LH-20 column chromatography.Their structures were elucidated by the spectral analysis.Compounds 1-5,7-13 are isolated from this species for the first time.Compound 8 showed antioxidant activity with a certain scavenging effect on DPPH (IC50 3.453 mg/mL),ABTS+ (IC50 0.155 mg/mL),and OH (IC50 0.019 mg/mL) radicals.

Key words: Aspergillus fumigatus, chemical constituent, structure identification, solid fermentation, antioxidant activity

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