NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2019, Vol. 31 ›› Issue (3): 380-386.doi: 10.16333/j.1001-6880.2019.3.002

Special Issue: No.8

• Article • Previous Articles     Next Articles

Combination of stem and leave of Scutellaria baicalensis and Ampelopsis grossedentata increases their antibacterial efficacy

ZHANG Lin1,SU Xiao-rong1,XU-Yuan1,XU Li-jia2,ZHU Zhen-hua1,ZENG Jian-guo3,ZHAO Ming1*,DUAN Jin-ao1*   

  1. 1Jiangsu Collaborative Innovation Center of Chinese Medicinal Ｒesources Industrialization,National and Local Collaborative Engineering Center of Chinese Medicinal Ｒesources Industrialization and Formulae Innovative Medicine, Key Laboratory of Chinese Medicinal Resources Recycling Utilization of State
    Administration of Traditional Chinese Medicine,Nanjing University of Chinese Medicine,Nanjing 210023,China; 2Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100093,China; 3National and Provincial Union Engineering Research Center for the Veterinary Herbal Medicine Resources and Initiative,Hunan Agricultural University,Changsha 410128,China
  • Online:2019-04-02 Published:2019-04-02

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Abstract: To study the antibacterial effect of combination of the stem and leave of Scutellaria baicalensis (SLSB) and Ampelopsis grossedentata (AG) aginst Staphylococcus aureus and Shigella dysenteriae,the micro broth dilution method was used to detect their MIC values.The time-bactericidal curves of SLSB and AG against S.aureus and S.dysenteriae were established as well.A checkerboard method and the fractional inhibitory concentration index (FIC index) were used to evaluate the interaction between SLSB and AG.The results showed that the MIC values of SLSB and AG against S.aureus were 1 mg/mL and 0.25 mg/mL,while against S.dysenteriae were 4 mg/mL and 0.50 mg/mL,respectively.And the FIC indices of combined SLSB and AG,0.750 for S.aureus and 0.625 for S.dysenteriae,revealed their additive interaction against the tested bacterials.The present experimental results thus indicated the potential to increase the antibacterial efficacy of SLSB by rational combination strategy,providing a practical way for the rational utilization of SLSB resource.

Key words: stem and leave of Scutellaria baicalensis, Ampelopsis grossedentata, antibacterial, resource utilization

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