Study on the isolation and indoleamine 2,3-dioxygenase inhibitory activity of salinomycin analogues

doi:10.16333/j.1001-6880.2019.6.014

Abstract

Abstract: To study the novel salinomycin analogues in the salinomycin fermentation product,in this work,two salinomycin analogues were prepared from the salinomycin fermentation product by preparative chromatography and subsequently characterized by spectroscopic means.Compound A was found to be 40-methyl salinomycin and compound B was found to be 35-methyl salinomycin,both of the analogues were new compounds.Biological activity studies indicated that compound B exhibited inhibitory activity against indoleamine 2,3-dioxygenase (IDO).

Key words: salinomycin-analogues, isolation, characterization, IDO inhibitory activity

CLC Number:

R914

ZHENG Cheng1,3,WANG Tao1,3,XIE Chang-xian2,YUN Xi-bao2,LU Xiao-xia1*. Study on the isolation and indoleamine 2,3-dioxygenase inhibitory activity of salinomycin analogues[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2019, 31(6): 1012-1016.

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Study on the isolation and indoleamine 2,3-dioxygenase inhibitory activity of salinomycin analogues

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