NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2021, Vol. 33 ›› Issue (7): 1112-1120.doi: 10.16333/j.1001-6880.2021.7.005

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Study on the chemical constituents from the aerial parts of Blumea balsamifera DC. and their antioxidant and tyrosinase inhibitory activities

ZHOU Li-qiang1,2,3,XIONG Yan1,2,5,CHEN Jun-lei1,2,ZHANG Jia-yu1,2,HAO Xiao-jiang1,2,4*,GU Wei1,2*   

  1. 1State Key Laboratory of Functions and Applications of Medicinal Plants,Guizhou Medical University;2The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences,Guiyang 550014,China;3Pharmacy School of Guizhou Medical University,Guiyang 550025,China;4Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,China;5Guiyang vocational and Technical College of Nursing,Guiyang 550081,China

  • Online:2021-07-28 Published:2021-07-29


To study the chemical constituents from the aerial parts of Blumea balsamifera DC. and their antioxidant and tyrosinase inhibitory activities. Eighteen compounds were isolated and identified from the aerial part of Blumea balsamifera DC. with various chromatographic techniques and spectroscopy methods,which were identified as 7,3′,4′-trimethylquercetin (1),4′,5-dihydroxy-3′,7-dimethoxyflavone (2),luteolin-7-methyl ether (3),rhamnetin (4),(2R,3R)-(+)-3,3′,5,7-tetrahydroxy-4′-methoxydihydroflavone (5),(2R,3R)-(+)-7′-O-methyldihydroquercetin (6),quercetin (7),luteolin (8),eriodictyol (9),isohemiphloin (10),isoquercetin (11),3-methoxyquercetin (12),ursolic acid (13),ursolic acid lactone (14),peroxyergosterol (15),2-hydroxy-4,6-dimethoxyacetophenone (16),2,4-dihydroxy-6-methoxyacetophenone (17),and methyl 3,4-dihydroxyphenyl lactate (18). Among them,compounds 10,14 and 18 were isolated from genus Blumea for the first time,and compound 13 was isolated from B. balsamifera for the first time. The antioxidant and anti-tyrosinase activities of these compounds were screened by using the DPPH free radical method and colorimetric method with L-tyrosine as substrat. The results showed that compounds 3-5,7-12 and 18 have strong antioxidant activities,and compounds 7,13,14,16,17 possessed certain tyrosinase inhibitory effects.

Key words: Blumea balsamifera, flavonoid, triterpenoids, antioxidant activity, tyrosinase inhibitory activity

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