Abstract: Nine compounds were isolated and purified from a deepsea actinomycete Actinomadura sp. 01119 by silica gel column,Sephadex LH-20 chromatography and PTLC.Their structures were identified as cyclo-(L-Phe-L-Pro) (1), cyclo-(L-Pro-L-Pro) (2), cyclo-(L-Tyr-L-Pro) (3), cyclo-(D-Tyr-L-Pro) (4), cyclo-(L-Ile-L-Pro) (5), cyclo-(L-Val-L-Pro) (6), hexadecanoic acid (7), p-hydroxybenzoic acid (8), uracil (9) by ¹H-NMR, ¹³C-NMR and MS.Compounds 1-6 are cyclic dipeptides.

Key words: deepsea actinomycete, Actinomadura sp. 01119, metabolites, cyclic dipeptide