Screening of Alkaloids Isolated from Medicinal Plant for MAO Inhibitory Activity

doi:10.16333/j.10016880.2016.S.031

Abstract

Abstract: To screen potential monoamine oxidase inhibitor from 24 alkaloids.24 alkaloids were isolated from five medical plants.The MAO inhibitory activity was tested by colorimetric method in 96well microplates.The result showed that among 24 alkaloids,Nnornuciferine(3)belonging to aporphinetype alkaloid obtained from Nelumbo nucifera showed a significant antiMAO activity with IC50 values of 40 μg/mL.The aporphinetype alkaloid may be a useful leading structure for MAO inhibitors.

Key words: MAO inhibitors, alkaloid, Nnornuciferine

CLC Number:

R284.1

CHEN Xiaowei*,YANG Zhongduo,ZHU Baoying,SUN Jianhui,ZHAO Junwen . Screening of Alkaloids Isolated from Medicinal Plant for MAO Inhibitory Activity[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2016, 28(增刊2): 319-322.

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Screening of Alkaloids Isolated from Medicinal Plant for MAO Inhibitory Activity

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