In this study,the mineral element contents in the soil of wild Rehmannia glutinosa production area was determined with microwave digestion-inductively coupled plasma-mass spectrometry(ICP-MS),and the distribution characteristics of the mineral element contents in the soil of the main production areas for wild R.glutinosa were analyzed with combined multivariate statistical method including hierarchical clustering analysis (HCA),principal component analysis (PCA),correlation analysis (CA),and so on.The results showed that 19 mineral elements were detected in 35 batches of soil from wild R.glutinosa production area.The content of the macronutrient element K was the highest.The content of the trace elements Fe,Al and Ti was higher than that of other elements except K.PCA and HCA results indicated that there was difference in the content of soil mineral elements between Henan and other wild R.glutinosa production areas,and they were grouped into two different categories.The content of Ti,Al,Mn,B,As,Mo,Cd and Sn in the soil of Henan area was remarkably different with that of other areas.The influence trend of the altitude on the content of mineral elements in the soil of wild R.glutinosa production area was different with regionality.Correlation analysis results showed that,the content of Mg in the soil was significantly positive-correlated with K,Al and Sr,the content of V was significantly positive-correlated with Cr,Ni and Co,and the content of Sr was significantly negative-correlated with Cr and V.In conclusion,the distribution of mineral elements in the soil of wild R.glutinosa production area is characterized by regionality.the contents of mineral elements in the soil of wild R.glutinosa production area in Henan is different from that of other production areas,and the contents of some elements in the soil have a significant correlation with each other.