Abstract: In order to improve the quality of Rhizoma coptidis pieces resulted by irregular processing method,procedure the influences of washing,infiltrating and drying were investigated to optimize the preparing procedures of R.coptidis pieces.Using single factor experiments and orthogonal test method with total alkaloids as evaluation index,the optimal preparation method of R.coptidis pieces was determined as follows:adding 2 times of water,washing once for 150 s,embellishing 60 s (under the condition of 125 ℃ and 0.10 MPa),sliceling and drying at 60 ℃ for 3.0 h.The preparing procedure is effective,stable and reliable．

Key words: Rhizoma coptidis pieces, preparation procedures, alkaloids