The purpose of the study was to investigate the effect of different proportions of Scutellariae Radix(SR) and Fritillariae Cirrhosae Bulbus (FCB) on the content of main chemical components in SR and the anti-pneumonia effect of equal proportions.SR and FCB was mixed in the ratios of 3∶0,3∶1,3∶2,3∶3,2∶3,1∶3,0∶3,and then extracted with water and determined by HPLC to determine baicalin,wogonoside,baicalein and wogonin.Thirty-six healthy ICR mice were randomly divided into six groups:control group,LPS group,treatment group,SR group,FCB group,and SRFCB group,six in each group.The drug was administered for 6 consecutive days.On the 7th day,the experimental group was injected intraperitoneally with 10 mg/kg of LPS,and the control group was injected with an equal volume of normal saline.LPS was used for 6 hours to determine the levels of IL-1β,IL-6 and TNF-α in the serum of the mice.The pathological changes of lung tissue of mice in each group were observed under light microscope.The results showed that the total content of baicalin,wogonoside,baicallein,wogonin was less than 6% when the compatibility ratio were 3∶1,3∶2,3∶3 and 2∶3.When the compatibility ratio reached 1∶3,the total amount of the four chemical components decreased by 23.7%.After equal proportions compatibility of SR and FCB,the levels of IL-1β,IL-6,TNF-α in the serum of mice were significantly reduced,and the pathological morphology of lung tissue was improved,and the therapeutic effect was better than that of the single drug group.It is advisable to control the proportions compatibility of SR and FCB to 3∶1-2∶3,and they have a synergistic effect in anti-pneumonia.