NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2018, Vol. 30 ›› Issue (4): 621-628.doi: 10.16333/j.1001-6880.2018.4.015

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Chemical Components and Antitumor Activity of Root Extract of Stellera chamaejasme L.

ZHAO Lin1, YANG Xi-hua2, YANG Yong-ming2, LI Shu-ping1, WANG Hui1, WANG Yue-feng1, ZHANG Sheng-wan1*   

  1. 1Shanxi University,College of Life Sciences,Taiyuan 030006,China; 2Shanxi Cancer Institute,Department of comparative medicine,Taiyuan 030013,China
  • Online:2018-05-07 Published:2018-05-07

Abstract: The components of the SRH which using hexane extracts the root of Stellera chamaejasme L.were analyzed by Gas Chromatography-Mass Spectrometry.Meanwhile,study the effects on H22 cancer mice.The results indicated that 44 structures of the root of Stellera chamaejasme L.were identified by GC-MS analysis,these included 12 kinds of hydrocarbon compounds,10 kinds of aromatic compounds,9 kinds of acids compounds,7 kinds of esters compounds,4 kinds of alcohols compounds and 2 other types of compounds.The contents above 1% of the root of Stellera chamaejasme L.were (Z,Z)-9,12-octadecadienoic acid,di-2-ethylhexyl phthalate,9,17-octadecadienal,triacontahexaene,.gamma.-sitosterol,dibutyl phthalate,n-hexadecanoic acid,octadecanoic acid,eicosanoic acid,whose total peak area is 90.74%,detection of squalene,linoleic acid,campesteral have certain antitumor activity ani-tumor which has not been reported in Stellera chamaejasme L.The SRH was effective in inhibiting the growth of the tumor;especially the low dose of SRH,the inhibition rate reached 21.5%.The results provide a theoretical basis for the analysis ofmaterial composition and anti-tumor effects about the roots of Stellera chamaejasme L.

Key words: the root of Stellera chamaejasme L., SRH, gas chromatography-mass spectrometry (GC-MS), hexane, anti-tumor

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