Abstract: Rheumatoid arthritis (RA) was characterized by synovial lesions which diseases were not only effect arthritis and surrounding small joints,but easily causes various complications.At present,there was no drug been found to completely cure RA,and its pathogenesis was not yet clear.The treatment of RA was mainly based on western medicine,supplemented by natural medicines,but it did not achieve the expected results,and the side effects of were large.Recent years,due to their security and efficient,flavonoids have been widely concerned by researcher domestic and foreign.This article summarized the sources and mechanisms of treatment on RA flavonoids at home and abroad in recent years and the pathogenesis of RA,then provided ideas for the study of the RA and the complications,and provided a scientific reference for the study of lipidomics as well as metabolomics.

Key words: flavonoids, mechanism, rheumatoid arthritis, inflammatory factor, NF-κBｐ65