NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2019, Vol. 31 ›› Issue (9): 1580-1584.doi: 10.16333/j.1001-6880.2019.9.014

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Secondary metabolites of endophytic fungus Fusarium tricinctum from Ningguo Peucedanum praeruptorum Dunn.

LIU Cong-bin1,LIU Hai-tao1,YANG Jai-sing2,LIU Jin-song1,WANG Gang1,WANG Guo-kai1 *   

  1. 1 School of Pharmacy,Anhui University of Chinese Medicine & Anhui Engineering Research Center of Modernized Chinese Material,Hefei 230012,China;

    2 Department of Medical Research,China Medical University Hospital,China Medical University,Taichung 40447,China

  • Online:2019-10-09 Published:2019-10-23

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Abstract: To study the secondary metabolites of endophytic fungus Fusarium tricinctum from Ningguo Peucedanum praeruptorum Dunn.Compounds were isolated from the EtOAc extract by chromatography technology and their structures were elucidated on the basis of comprehensive spectroscopic analysis.Thirteen compounds were isolated and their structures were identified as cyclo-(L-pro-L-pro) (1),cyclo-(S-pro-S-leu) (2),cyclo-(L-phe-L-phe) (3),cyclo-(D-pro-L-phe) (4),cyclo-(L-pro-L-phe) (5),cyclo-(D-pro-L-leu) (6),cyclo-(S-pro-S-leu) (7),cyclo-[D-(4-hydroxyprolinyl)]-(L)-leucine (8),cyclo-[L-(4-hydroxyprolinyl)]-(L)-leucine (9),cyclo-(trans-4-hydroxy-L-prolyl-L-phenylalanine) (10),cyclo-(D-cis-hyp-L-phe) (11),benzyl benzoate (12),phenylacetic acid (13).All these compounds were isolated from Fusarium tricinctum for the first time.The cytotoxicity assay showed that compounds 4,6 and 7 had moderate cytotoxic activities against CAR,CAL27,SCC-4,SCC-9,and HSC-3.

Key words: endophytic fungus, Ningguo Peucedanum praeruptorum Dunn., Fusarium tricinctum, secondary metabolites, anti-tumor

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