Study on Self-microemulsifying Drug Delivery System Formulation for Solanum nigrum Alkaloids

Abstract

Abstract: The aim of this study was to find the optimal self-microemulsifying drug delivery system (SMEDDS) formulation for Solanum nigrum alkaloids.The effects of the contents of Tween-20, polyoxyethylene octyl phenyl ether,oleic acid,1,2-propanediol and S.nigrum alkaloids on the particle diameter and light transmittance of SMEDDS for S.nigrum alkaloids were investigated.The optimized ingredients for preparing SMEDDS for S.nigrum alkaloids provided reference for further studies on its pharmacodynamics.

Key words: Solanum nigrum, alkaloid, self-microemulsifying drug delivery system, particle diameter

CLC Number:

ZHANG Wei1, JIA Xiao-bing2, LIU Mei-hui1, ZHU Jin-hua1*. Study on Self-microemulsifying Drug Delivery System Formulation for Solanum nigrum Alkaloids[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2014, 26(7): 1112-1116.

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Study on Self-microemulsifying Drug Delivery System Formulation for Solanum nigrum Alkaloids

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