Abstract: Based on the theory of traditional Chinese medicine coordination chemistry,an AP-Sm complex was synthesized with anti-inflammatory and anti-gout agent apigenin (AP) as a ligand,and rare earth metal Sm (Ⅲ) ion as coordination center to improve the activity of anti-hyperuricemia.The chemical structure of the AP-Sm complex was characterized by UV,IR,and ¹H NMR,conductometry and TG-DTA.Effect of AP-Sm complex on uric acid (UA) level,xanthine oxidase (XOD) activity and superoxide anion (SOA) level in hyperuricemia mice induced by yeast extract combined with potassium oxazinate was investigated respectively.The results showed that AP-Sm complex was coordinated through 5-OH and 4-C=O of apigenin with Sm (Ⅲ) ion.The coordination ratio of AP to Sm(Ⅲ) was 3.The study on the activity of anti-hyperuricemia found that AP-Sm complex was superior to AP in inhibiting XOD,removing SOA,reducing SUA and promoting UA excretion ability.Compared with apigenin,the AP-Sm complex showed increased anti-hyperuricemia activity after the coordination of apigenin to Sm (Ⅲ) ion.

Key words: apigenin, rare earth, coordination complex, hyperuricemia, xanthine oxidase inhibitor