玄参属植物中环烯醚萜类成分及其生物活性研究进展

doi:A

摘要/Abstract

摘要： 本文综述了近年来从玄参属植物中分离得到的所有环烯醚萜类成分及其生物活性，为该属植物及该类成分的深入开发和利用提供参考。

Abstract: Scrophularia species,widely distributed in the world,have been used as folk remedies for some medical treatment including tumours, parasitic diseases and inflammatory affections.The iridoid glycosides are the main and rich classes of substances. Now,there are nearly 80 iridoid compositions isolated and identified from these species,which have been shown antiinflammatory, neuroprotective,hypoglycemic, hepatoprotective, immuno-modulator,antiprotozoal,antibacterial activities according to the study of pharmacology.This review summarizes the iridoids and their biological activity associated with the species,as refer to their future investigation.

中图分类号:

Q284.2

龚友兰，潘琦虹，向大雄. 玄参属植物中环烯醚萜类成分及其生物活性研究进展[J]. 天然产物研究与开发, 2012, 23(3): 406-413.

GONG You-lan, Pan Qi-hong, XIANG Da-xiong. Advances in Studies on Iridoids in Plants of Scrophularia L. and Their Bioactivity[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2012, 23(3): 406-413.

参考文献

1 Flora of China,18.Beijing:Scinece Publishing House,1998:11-20.
2 Chinse Pharmacopeia(中国药典),Vol.1.Beijing:Chemical Industry Publishing House,2005:78.
3 J de Santos Galíndez,et al.Biologically active substances from the genus scrophularia.Pharmaceutical Biology,2002,40:45-59.
4 Dong JE(董娟娥),Zhang Jing(张靖).Adavances in the research of iridoids occuring in plants.J Northwest Forestry Univ(西北林学院学报),2004,19(3):131-135.
5 Deniz Tasdemir,et al.Anti-protozoal and plasmodial FabI enzyme inhibiting metabolites of Scrophularia lepidota roots.Phytochemistry,2005,66:355-362.
6 Michael Stavri,et al.Antimicrobial constituents of Scrophularia deserti.Phytochemistry, 2006,67:1530-1533.
7 Chen X,et al.Iridoid glycosyl esters from Scrophularia ningpoensis.Nature Product Research,2007,21:1187-1190.
8 So Ra Kim,et al.Four new neuroprotective iridoid glycosides from Scrophularia buergeriana roots.J Nat Prod,2002,65:1696-1699.
9 Deniz Tasdemir,et al.Evaluation of antiprotozoal and antimyco-bacterial activities of the resin glycosides and the other metabolites of Scrophularia cryptophila.Phytomedicine,2008,15:209-215.
10 Calis I,et al.Karsoside and Scropolioside D,two new iridoid glycoside from S.ilwensis.J Nat Prod,2003,26:606-609.
11 Fernandez Matellano L,et al. Iridoids from S.Scorodonia.Planta Med,1995,61(1):93.
12 Zou CHT (邹臣亭),Yang XW(杨秀伟).A new iridoid glucoside from ningpo figwort (scrophularia ningpoensis) root.Chin Tratit Med(中草药),2000,31:241-243.
13 Yi-Ming Li,et al.Iridoid glycosides from Scrophularia ningpoesnsis.Phytochemistry, 1999,50:101-104.
14 Chebaki rachild.Etude des composes chimiques de Scrophularia saharae(deserti coss).
15 C Faivre. Scrofularia nodosa.Phytotherapie,2007,5(3):154-158.
16 Bin Chen,et al.Iridoid and phenylpropanoid glycosides from Scrophularia ningpoensis Hemsl. Asian Journal of Traditional Medicine,2007,2(3):118-123.
17 Tetsuya Kajimoto,et al.Iridoids from Scrophularia ningpoensis.Phytochemistry,1989, 28:2701-2704.
18 Zhang WJ(张雯洁),et al.Iridoidal glycosides from Scrophularia spicata. Acta Botanica Yunnanica(云南植物研究),1992, 14:437-441.
19 Lidia Fernandez,et al.An iridoid diglycoside isolated from Scrophularia scorodonia. Phytochemistry,1995, 40:1169-1571.
20 Toshio Miyase,Ai Mimatsu.Acylated iridoid and phenylethanoid glycosides from the aerial parts of Scrophularia nodosa.J Nat Pro,1999,62:1079-1085.
21 De santos J,et al.Catapol glycosides from Scrophularia scorodonia.Pharmazia,1998, 53(427):54.
22 Jingfang Qian,et al.Iridoid-related aglycone and its glycosides from S.ningpoensis. Phytochemistry,1992, 31:905-911.
23 Swiatek L,Lhemann D.Iridoid glycosides of Scrophularia lateriflora trautv (Scrophulariacea).Pharm Acta Helv,1981,56(1):37-48.
24 Pachaly P,et al.Isolierung and strukturaularung neuer iridoid glycosides from aus Scrophularia koraiensis.Pharmazie,1994,49:150-155.
25 Berini R,et al.Iridoids in the flora of Italy12 isolation and partial synthes of 7,8-dehydro-6β,10-dihydroxy-11-noriidomyrmecin，a methycyclopentanoid monoterpene from S. canina.J Nat Prod,1991,54:1400-1403.
26 Giner RM,et al.A new iridoid from Scrophularia auriculata ssp. Pseudoauriculata.J Nat Prod, 1998,61:1162-1163.
27 Bahar Ahmed,et al.Scropolioside-D2 and harpagoside-B:two new iridoid glycosides from scrophularia deserti and their antidiabetic and antiinflammatory activity.Biol Pharm Bull,2003,26:462-467.
28 Calis Gross GA,et al.Isolation and structure elucidation of two highly acylated iridoid diglycosides from Scrophularia Scopolii.Planta medica,1988,54:168-170.
29 Anh-Tho Nguyen,et al.A sugar ester and an iridoid glycoside from Scrophularia ningpoensis. Phytochemistry,2005,66:1186-1191.
30 Bhandari SPS,et al.Koelzioside, an iridoid diglycoside from scrophularia Koelzii.Phytochemictry, 1992,31:689-691.
31 Lin SJ,et al.Two novel iridoids from Scrophularia buergeriana.Tetrahedron Lett,2000,41:1069-1071.
32 Lin SJ,et al.C9-Iridoids from Scrophularia buergeriana.Helvetica Chimica Acta,2006, 89:2789-2794.
33 Dong-Hyun Kim,et al.Mechanism of covalent adduct formation of aucubin to proteins. Toxicology Lett,2000,114:181-188.
34 Hyun-Ja Jeong,et al.Inhibition of TNF-α and IL-6 production by aucubin through blockage of NF-κB activiation in RBL-2H3 mast cells.Cytokine,2002,18:252-259.
35 Tom Hsun-Wei Huanga,et al.Harpagoside suppresses lipopolysaccharide-induced iNOS and COX-2 expression through inhibition of NF-κB activation.J Ethnopharmacology, 2006,104 (1/2):149-155.
36 Nassima Abdelouahab,Charles Heard.Effect of the major glycosides of Harpagophytum procumbens (Devil’s Claw) on epidermal cyclooxygenase-2 (COX-2) in vitro.J Nat Prod,2008, 71:746-749.
37 Kerstin Boje,et al.New and known iridodi and phenylthanoid glycoside from harpagophytum procumbens and their in vitro inhibition of human leukocyte elastase.Planta medica,2003,69:820-825.
38 Esperanza Bas,et al.New insight into the inhibiton of the inflammatory response to experimental delayed-type hypersensitivity reations in mice by Scropolioside A.Europeanjournal of pharmacology, 2007,555:199-210.
39 Rosa-Maria Giner,et al.Anti-inflammatory glycoterpenoids from Scrophularia auriculata. European journal of pharmacology,2000,389:243-252.
40 Maria del Carmen Recio,et al.Structural considerations on the Iridoids as anti-inflammatory Agents.Planta Med,1994,60:232-234.
41 Paulina Bermejo,et al.Antiviral activity of seven iridoids,three saikosaponins and one phenylpanoid glycoside extracted from buleurum rididum and Scrophularia scorodonia.Planta medica, 2002,68:06-110.
42 So Ra Kim,et al.Iridoids from Scrophularia buergeriana attenuate glutamate-induced neurotoxicity in rat cortical cultures.J Neuroscience Res,2003,74:948-955.
43 Eun Ju Jeong,et al.Cognitive-enhancing and antioxidant activities of iridoid glycosides from Scrophularia buergeriana in scopolamine-treated mice.European Journal of Pharmacology,2008, 588:78-84.
44 Lei Jin,et al.Antioxidant and pancreas-protective effect of aucubin on rats with streptozotocin-induced diabetes.European Journal of Pharmacology,2008,582:162-167.
45 Garg HS,et al.Antihepatotoxic and immunostimulant properties of iridoid glycosides of Scrophularia koelzii.Phytotherapy Res,1994,8:224-228.
46 Philip C,et al.Wound healing activity of acylated eridoid glycosides from Scrophularia nodosa. Phytotherapy Res,2002,16(1):33-35.

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